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The Westmead Hospital Gastrointestinal Endoscopy research team lead by Professor Michael Bourke has produced several internationally relevant, practice changing studies. Key amongst these is the Australian Colonic Endoscopic Resection (ACE) study, a multi-centre project involving 14 endoscopy units across Australia that enrols patients referred for the removal of large colonic polyps at risk of progressing to cancer.

The ACE study has enrolled over 3000 patients and showed that endoscopic resection can be performed as a day case procedure, has few complications, is highly effective and significantly less costly than surgery. Results of this study have informed the standard of care and is a cornerstone study in national and international guidelines on endoscopic resection in the colon. The study has resulted in over 25 publications in international journals. The department has produced several prospective studies and randomized trials on areas including Barrett’s oesophagus, duodenal adenomas, ERCP, EUS, polyp characterisation and in prediction of cancer and sessile serrated polyps. It has ongoing projects on Endoscopic Submucosal Dissection (ESD) and Per-Oral Endoscopic Myotomy (POEM). A key research area is the resection of early cancers in the gastrointestinal tract by ESD.

The Storr Liver Centre is an internationally renowned research centre that undertake clinical, basic and bench-to-bedside research on all aspects of liver disease, with specific themes in fatty liver, hepatitis C, hepatitis B, liver cancer, liver fibrosis, liver disease genetics, liver immunology, the bioinformatics of liver disease and in drug metabolism and pharmacogenomics. The Centre publishes over 75 papers annually in very high impact journals including the New England Journal of Medicine, Nature, Nature Genetics, Cell and Cell Metabolism. Research output from the unit is highly cited and underpins much of current practice in clinical Hepatology.

 

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